RNA Details
Disease Name
lens fibrosis
Tissue
eye
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
RT-PCR; cell prolimmunofluorescenceeration etc.
Target
MIRNA-21?
Pathway
TGF-BETA SIGNALING PATHWAY; SMAD SIGNALING PATHWAY
PubMed ID
Title
MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy
Year
2015
Function
"The present study shows that mir-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from tao, and acts as a mediator in tgf-beta1-induced collagen production. These data predict a close association between mir-21 and orbital muscle fibrosis, and provide a novel therapeutic target for tao."